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Imaging quality assessment of multi-modal miniature microscope — Alliance for NanoHealth
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Junwon Lee, Jeremy Rogers, Michael Descour, Elizabeth Hsu, Jesse Aaron, Konstantin Sokolov, and Rebecca Richards-Kortum (2003)

Imaging quality assessment of multi-modal miniature microscope

Optics Express 11(12):1436-1451.

We are developing a multi-modal miniature microscope (4M device) to image morphology and cytochemistry in vivo and provide better delineation of tumors. The 4M device is designed to be a complete microscope on a chip, including optical, micro-mechanical, and electronic components. It has advantages such as compact size and capability for microscopic-scale imaging. This paper presents an optics-only prototype 4M device, the very first imaging system made of sol-gel material. The microoptics used in the 4M device has a diameter of 1.3 mm. Metrology of the imaging quality assessment of the prototype device is presented. We describe causes of imaging performance degradation in order to improve the fabrication process. We built a multi-modal imaging test-bed to measure first-order properties and to assess the imaging quality of the 4M device. The 4M prototype has a field of view of