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"Trojan Horse" Delivers Drug-Loaded Nanoparticles Deep Into Tumors

One of the most difficult feats to accomplish with today's anticancer therapies is getting drug into the oxygen- and nutrient-deprived cores of solid tumors. These inaccessible regions may be the source of drug-resistant tumors that can recur years after a patient has completed therapy. One type of cell, however, seems to be able to penetrate the tumor mass, and in fact, these cells, known as macrophages, can account for up to 70 percent of the tumor mass in malignancies such as breast cancer. Unfortunately, these tumor-associated macrophages (TAMs) promote rather than impede tumor progression and foster metastasis.

     
 
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